Bone Metabolism Research Group

Group leader: Harjit Pal Bhattoa MD, PhD, DSc.

Members: Edit Kalina BSc; József Király MD; Zoltán Mezei MD, PhD; Zoltán Pap MD, PhD; Szilvia Rácz MSc; Gábor Tóth MD, PhD

Technician: Erika Szakácsné Szilágyi

 

Background: The epidemiology, diagnosis and treatment of bone mineral disease, osteoporosis in particular, has been a topic of intense research in the near past. The lack of knowledge on the prevalence of the condition can hinder formulation of efficient healthcare objectives. Keeping Falls in focus, the main trigger that may result in a fracture, research on sarcopenia is mandated with the same intensity as any other bone and muscular disorder.

Areas of interest: Our focus has dwelled upon the study of primary and secondary osteoporosis. The assessment of osteoporosis prevalence and vitamin D insufficiency in healthy Hungarian women and men has highlighted the risk factors implicated. It has, furthermore, highlighted the need for standardization of methodology used to determine 25-hydroxyvitamin D levels. Studies on secondary osteoporosis, i.e, SLE, RA, PsA, T2DM has helped understand the health implications of poor bone health and vitamin D insufficiency. In the near past, prevalence of sarcopenia was determined in the local population, studies to identify potential biomarkers in the condition are ongoing. With an ever increasing interest in research using big data, lately the research group is analyzing the trends in Vitamin D levels using data generated between 2000 and 2020.

Methodology: Bone mineral density and total body composition are studied using Dual Energy X-ray Absorptiometry. Various immunoassay, particularly ECLIA, CLIA and ELISA are used to assess known and novel biomarkers.

Collaborating Scientists: Markus Hermann, University of Graz, Austria; Etienne Cavalier, University of Liege, Belgium.

 

List of the most relevant publications:

 

  1. Bhattoa HP, Kiss E, Bettembuk P, Szegedi G, Balogh A. Bone Mineral Density, Biochemical Markers of Bone Turnover and Hormonal Status in Men with Systemic Lupus Erythematosus. Rheumatol Int 2001;21(3):97-102
  2. Bhattoa HP, Bettembuk P, Balogh A, Szegedi G, Kiss E. Bone mineral density in women with systemic lupus erythematosus. Clin Rheumatol 2002;21(2):135-41
  3. Bhattoa HP, Bettembuk P, Ganacharya S, Balogh A. Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. Osteoporosis Int 2004;15(6):447-51
  4. Bhattoa HP, Nagy E, More C, Kappelmayer J, Balogh A, Kalina E, Antal-Szalmas P. Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age. The HunMen Study. Osteoporosis International 2013;24(1):179-186
  5. Bhattoa HP, Wamwaki J, Kalina E, Foldesi R, Balogh A, Antal-Szalmas P. Serum sclerostin levels in healthy men over 50 years of age. J Bone Miner Metab. 2013;31(5):579-584.
  6. Bhattoa HP, Onyeka U, Kalina E, Balogh A, Paragh G, Antal-Szalmas P, Kaplar M. Bone metabolism and the 10-year probability of hip fracture and a major osteoporotic fracture using the country-specific FRAX algorithm in men over 50 years of age with type 2 diabetes mellitus: a case-control study. Clin Rheumatol. 2013;32(8):1161-7.
  7. Petho Z, Kulcsar-Jakab E, Kalina E, Balogh A, Pusztai A, Gulyas K, Horvath A, Szekanecz Z, Bhattoa HP. Vitamin D status in men with psoriatic arthritis: a case-control study. Osteoporosis Int 2015; 26:1965–1970 DOI 10.1007/s00198-015-3069-2
  8. Kulcsar-Jakab E, Petho Z, Pap Z, Kalina E, Foldesi R, Balogh A, Antal-Szalmas P, Bhattoa HP. Cystatin C as a potential predictor of osteoprotegerin levels in healthy men. A cross-sectional, observational study. BMC Musculoskeletal Disorders 2015;16(1):227. doi: 10.1186/s12891-015-0684-1.
  9. Jakab E, Kalina E, Petho Z, Pap Z, Balogh A, Grant WB, Bhattoa HP. Standardizing 25-hydroxyvitamin D data from the HunMen cohort. Osteoporos Int 2017;28:1653-1657. doi: 10.1007/s00198-017-3924-4.
  10. Bhattoa HP. Laboratory aspects and clinical utility of bone turnover markers  eJIFCC. 2018;29(2):117-128.
  11. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020 Apr 2;12(4). pii: E988. doi: 10.3390/nu12040988.
  12. Petho Z, Kalina E, Pap Z, Hodosi K, Falcsik R, Balogh R, Szekanecz Z, Bhattoa HP. Characterization of bone metabolism in hungarian psoriatic arthritis patients: a case–control study. BMC Musculoskeletal Disorders (2021) 22:70.
  13. Pap Z, Kalabiska I, Balogh Á, Bhattoa HP. Prevalence of sarcopenia in community dwelling outpatient postmenopausal Hungarian women. BMC Musculoskelet Disord. 2022 Mar 4;23(1):207. doi: 10.1186/s12891-022-05167-2.
  14. Pap Z, Kalabiska I, Balogh Á, Bhattoa HP. Evaluation of the sarcopenia quality of life (SarQoL) questionnaire in community dwelling outpatient postmenopausal hungarian women. BMC Musculoskelet Disord. 2023 Apr 27;24(1):331. doi: 10.1186/s12891-023-06454-2.

 

Frissítés dátuma: 2024.04.11.